BIBB 515

CAS No. 156635-05-1

BIBB 515 ( BIBB 515; BIBB-515; BIBB515 )

Catalog No. M19346 CAS No. 156635-05-1

BIBB 515 is a selective and potent inhibitor of OSC in vivo with an ED50 value of 0.2-0.5 and 0.36-33.3 mg/kg in rats and mice, respectively.

Purity : 98%

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    BIBB 515
  • Note
    Research use only, not for human use.
  • Brief Description
    BIBB 515 is a selective and potent inhibitor of OSC in vivo with an ED50 value of 0.2-0.5 and 0.36-33.3 mg/kg in rats and mice, respectively.
  • Description
    BIBB 515 is a selective and potent inhibitor of OSC in vivo with an ED50 value of 0.2-0.5 and 0.36-33.3 mg/kg in rats and mice, respectively. 2, 3-Oxidosqualene cyclase (OSC) is an important enzyme in the biosynthesis of animal, plant, and fungal sterols. OSC catalyzes the conversion of (3S)-2, 3-oxidosqualene to lanosterol, a precursor to cholesterol, in mammals and fungi. Total cholesterol was reduced by 19% in normolipemic hamsters at a dose of 55 mg/kg/day for 11 days and 25% in hyperlipemic hamsters at a dose of 148 mg/kg/day for 25 days.
  • Synonyms
    BIBB 515; BIBB-515; BIBB515
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    OSC
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    156635-05-1
  • Formula Weight
    380.87
  • Molecular Formula
    C22H21ClN2O2
  • Purity
    98%
  • Solubility
    ——
  • SMILES
    Clc1ccc(cc1)C(=O)N1CCC(CC1)=Cc1ccc(cc1)C1=NCCO1
  • Chemical Name
    1-(4-Chlorobenzoyl)-4-((4-(2-oxazolin-2-yl) benzylidene))piperidine

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Eisele, B., Budzinski, R., Müller, P., et al. Effects of a novel 2,3-oxidosqualene cyclase inhibitor on cholesterol biosynthesis and lipid metabolism in vivo. Journal of Lipid Research 38, 564-574 (1997).
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